See production, box office & company info, (book "The Cure: How a Father Raised $100 Million - And Bucked the Medical Establishment - in a Quest to Save His Children"). Inspired by the book "The Cure" by Pulitzer Prize Winning Writer Greeta Anand. Stonehill generally explains the basics of Pompe disease and his experimental cure, but the viewer is always kept at a distance from the drama of the research itself. In the new film Extraordinary Measures, Harrison Ford does what he does best. The "suggestive moment" involves a very brief scene when the Crowleys' personal nurse interrupts them during a moment of intimacy; though nothing is shown and it's intended for laughs, it's completely extraneous. Incomprehension. They have Pompe disease, a rare genetic disorder caused by an enzyme deficiency that leads to muscle weakness and typically death by 9 years of age. The FSHD Society was founded on the idea that we had to do something extraordinary to discover the cause and cure for FSHD. "I was at home in New Jersey, holding day-to-day life together," says Aileen, 41. Those ambitions have a good chance of being realized. The purpose was to simplify things while adding suspense, having Crowley butt heads against one scientist instead of several, but it seems disingenuous in the postscript of the film to assert that "Stonehill's" research continues. Steering her electric wheelchair along the red carpet in Manhattan later this week, 13-year-old Megan Crowley will be pinching herself to prove it's not fantasy. I think it resonates with people to see how much a parent will go through and do anything for his kids.. As for the Crowleys, beyond Thursday's glitzy New York premiere, they look forward to a rosy future. Filming took place at several spots in and around Portland, Oregon, mostly at the OHSU Doernbecher Children's Hospital, Veterans Affairs Medical Center and the Nike campus in Beaverton, Oregon. While their older son, John Jr., then 3, was healthy, his newborn brother, Patrick, also suffered. Fate and determination push idealistic father, John Crowley (Brendan Fraser, The Mummy) into joining forces with reclusive medical researcher, Dr. Robert Stonehill (Academy Award nominee Harrison Ford, Best Actor in a leading role, Witness, 1985). "Megan plans to go to Stanford University and become either a teacher or a fashion designer," says John. And no wonder. A timely subject with health care on the minds of millions. Dr. Robert Stonehill: I already work around the clock! While the pandemic negatively impacted many muscular dystrophy funding organizations, your steadfast support has allowed us to meet this extreme need, ensuring the best research will be funded and move forward. The movie's tagline reads, "Don't hope for a miracle. Nevertheless, Crowley gives it his all: "I can't just sit there while my kids are dying." Department 960, P O Box 4106 "I have a tiny little plaque on my desk which my mom gave me the week I started that tiny company. Sadly, it all adds up to an extraordinary bore. The family seems to be out of options, but a near-death experience for Megan at the hospital prompts John to reach out to Dr. Robert Stonehill (Ford), a scientist at the University of Nebraska whose experimental research may hold a cure for Pompe children. In 2000, despite having limited experience in the medical world, he traveled the globe, consulting experts in the field. How do we discern God's will in the matter? We think the gene therapy aspect will work alongside the traditional treatment. Myozyme, a drug developed for treating Pompe disease, was simultaneously approved for sale by the US Food and Drug Administration and the European Medicines Agency. Depicted as an eccentric loner, Stonehill's eccentricities are limited to working late, not answering the phone, and playing loud rock music while working. . Brendan Fraser, Harrison Ford, Keri Russell. Is there a scenario where it's better for the kids to "accept fate"? For Pompe disease, the general therapy involving intravenous infusions helps slow the progression, but we want to give it a hand. It's that you feel, at the end, that you have learned something about the way the world works. "There were plenty of times when the science was tough and the business was tough and I didn't want to be away from the family," recalls John. John learns of some promising research by a university scientist, Dr. Robert Stonehill, played by Harrison Ford. Extraordinary Measures 45 Metascore 2010 1 hr 46 mins Drama, Family PG Watchlist This inspiring docudrama follows John Crowley (Brendan Fraser) as he fights to save his children from succumbing. As the first feature from the newly formed CBS Films, Extraordinary Measures feels like a TV movie that happens to star Fraser and Fordneither actor distinguishes himself here. Also starring Golden Globe winner Kerri Russell, Extraordinary Measures is a true story of the power of love and faith against impossible odds. (Or alternately, that you cant see past the stereotyped version of your own bailiwick.) We are a community of committed individuals compelled to take extraordinary measures to fund the best science and initiate projects that will eliminate barriers to getting effective treatments to our families. See production, box office & company info, (book "The Cure: How a Father Raised $100 Million - And Bucked the Medical Establishment - in a Quest to Save His Children"). But all is not well. This community participates in surveys, testifies before the FDA, and serves on biopharmaceutical advisory groups. "Extraordinary Measures" opens in theaters Friday. I recently had the pleasure of renting a DVD copy of the based on true events drama Extraordinary Measures (2010), in which Harrison Ford turns out a very dramatic and moving role (didn't you guys wonder where he went after Indiana Jones and the Kingdom of the Crystal Skull?). The true story of Barry Byrne's efforts to cure Pompe disease is even more compelling than the movie. This year we will invest approximately $1 million to move these initiatives forward extraordinary measures. We may earn a commission from links on this page. [19], Jef Akst, writing for the journal The Scientist, stated that the film is good depiction of the "hard to swallow fiscal issues of drug development."[20]. Apple TV & Privacy John's business developed a drug that showed promising results. She received several treatments as part of the final clinical trial and then became the first patient to receive the treatment on a commercial basis. Support, Available on Pluto TV, Paramount+, Prime Video, iTunes. If anyone could do it, he could. Her father is John Crowley ( Brendan Fraser ), an executive at Bristol-Myers Squibb. In a first-in-humans gene therapy for neuromuscular disease, clinical scientists led by Byrne will infect cells of Pompe patients with the genetic machinery they have been missing since birth. John takes on the task full-time to save his children's lives, launching a biotechnology research company working with venture capitalists and then rival teams of researchers. Pas : USA "Medidas extraordinarias" pelcula de drama producida en USA. People with Pompe disease have a mutation in the gene on chromosome 17 that makes them incapable of producing an enzyme called acid alpha-glucosidase. This network is activating the powerful forces of an educated, empowered, and engaged community that will stop at nothing to facilitate treatments to our families extraordinary measures. In a study of mice with the disease, Byrne and colleagues attached a functional copy of the gene that produces GAA the missing enzyme in Pompe patients to the AAV virus and injected it into the diaphragm muscle, where the virus infected cells and thus introduced the functional gene. The Crowleys were told the grim news that 15-month-old Megan had a rare muscle-wasting condition, Pompe disease. Director Jon Erwin discusses his inspiration for the film and how history might be repeating itself today. Apple Inc. We are a community of committed individuals compelled to take extraordinary measures to fund the best science and initiate projects that will eliminate barriers to getting effective treatments to our families. Browse 60+ years of magazine archives and web exclusives. In many areas of medicine, a combination of treatments is used to benefit the patient, and we hope the gene therapy approach will work in the same way.. On this Wikipedia the language links are at the top of the page across from the article title. The veteran actor brings to life another curmudgeonly character who, once his prickly exterior is stripped away, is. A drama centered on the efforts of John and Aileen Crowley to find a researcher who might have a cure for their two children's rare genetic disorder. Randolph, MA 02368 U.S.A. Discovering the Cause and the Cure for FSHD. As anyone with an understanding of "orphan drugs" and the pharmaceutical industry knows, miracle cures don't simply develop overnight. Studies have given us encouraging evidence that gene therapy for some very devastating diseases is a realistic possibility, Byrne says. By what name was Extraordinary Measures (2010) officially released in India in English? Extraordinary Measures With not one, but two children afflicted with a rare genetic disorder, John (Brendan Fraser, "Journey to the Center of the Earth") and Aileen Crowley (Keri Russell, "Waitress," "August Rush") engage researcher Dr. Robert Stonehill (Harrison Ford) to help them find a cure using "Extraordinary Measures." A decade ago, UF molecular geneticist Barry Byrne was just beginning to develop methods for transferring missing genes into people with Pompe disease, a rare form of muscular dystrophy. If only it were that simple. Patrick (Diego Velazquez) gets some encouragement from Mom. Extraordinary Measures - Watch Full Movie on Paramount Plus. [11] According to Roger Ebert's review, the character is based on Yuan-Tsong Chen,[6] a scientist and researcher from Duke University[12] who collaborated with Genzyme in producing Myozyme, the drug which received FDA approval. A drama centered on the efforts of John and Aileen Crowley to find a researcher who might have a cure for their two children's rare genetic disorder.A drama centered on the efforts of John and Aileen Crowley to find a researcher who might have a cure for their two children's rare genetic disorder.A drama centered on the efforts of John and Aileen Crowley to find a researcher who might have a cure for their two children's rare genetic disorder. Brendan Fraser, Harrison Ford, Keri Russell. Except the Stonehill character is abrasive and world weary, while Byrne is affable and tirelessly optimistic. Copyright 2023 Two high-profile actors in Brendan Fraser and Harrison Ford. Watch Now. Grief. Extraordinary Measures is a 2010 American medical drama film starring Brendan Fraser, Harrison Ford, and Keri Russell. This was the first time Nike allowed filming on their campus and they donated the location payment to Doernbecher Childrens Hospital. 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