83, no. 289294, 2010. ). 3 E. A. Pritts, Letrozole for ovulation induction and controlled ovarian hyperstimulation, Current Opinion in Obstetrics and Gynecology, vol. Since the treatment goal differs in women with ovulation dysfunction (1-2 ovulations) versus women undergoing controlled ovarian hyperstimulation with other diagnoses (2-3 ovulations or more), these groups were separated and compared (Table 2) [8]. A. R. Baerwald, R. A. Walker, and R. A. Pierson, Growth rates of ovarian follicles during natural menstrual cycles, oral contraception cycles, and ovarian stimulation cycles, Fertility and Sterility, vol. Predicted ovulation number was greater for increasing doses of the drug, and endometrial thickness was unaffected. If the lead follicle size is relatively small (14.1-18.0 mm) when a spontaneous LH surge occurs, there is no need to cancel the IUI cycle. 2017 Jul-Sep;8(3):116-121. doi: 10.4103/jpp.JPP_43_17. They tend to grow 2mm per day so yes u still have some hope for this cycle but re should consider upping your dose and starting u on it at cd 3. Meledaisy- Thank you so much for sharing your story and experience. I'm 39 so they're good with me having three follicles. (Again, no medical background. Any advice is so appreciated - thank you! ). I didn't have an ultrasound until day 13 so I am not sure what I had at day 11. Group Black's collective includes Essence, The Shade Room and Naturally Curly. Does anyone have any insight? I use Mira OPKs just for that reason. And yea follicles can get really big and become harmful cycsts but its not usually the case. This is EXACTLY what happend to me this month! < I was hoping to get some advice from you all. ) and first 12.5mg/day cycles ( Furthermore, randomized trials are needed to determine whether high-dose letrozole might actually be optimal as a starting dose for certain treatment groups. I have to go to my gyn on the 20th of this month to have a follow up u/so to see if they are shrinking or not. Data were analyzed using the Statistical Package for the Social Sciences (SPSS) program. Intervention(s): Did they say what size they want it to be? Okay so I had something similar happen to me my first iui go around. Results indicate that such doses do indeed offer benefit to patients; in that there is increased follicular growth and a higher number of predicted ovulations with higher doses of the drug. If a woman started Femara treatment on day 3 of her cycle, she would likely ovulate between days 10-13. official website and that any information you provide is encrypted Does this seem a bit early or am i paranoid? 0 #2 Blue12, Nov 23, 2010. 687, pp. Group Owners uphold the core values of the brand by reporting content that violates the community guidelines. On the day of hCG administration women were randomly categorized into two groups according to a computer generated random numerical table. So my bigger follicle had not grown but 1mm in 4 days and the other smaller one looked like it had some fluid accumulating around it. Last time, my progesterone levels were really good, so I feel ok w that plan. As a result of that I was bumped up to 100iu of gonal-f starting I cd 6. think twice before sharing personal details, foster a friendly and supportive environment, remove fake accounts, spam and misinformation, delete posts that violate our community guidelines, reviewed by our medical review board and team of experts. Had an ultrasound today (CD 10) to see how things are going but unfortunately the biggest follicle was only around 9mm. Please specify a reason for deleting this reply from the community. They gave fluids and an ultra sound and blood work. Baby dust . An analysis of 988 cycles The optimal size of the leading follicle in cycles with clomiphene citrate and letrozole is in the range of 23-28 mm and is closely related to the endometrial thickness. We all struggle with infertility here. Im wondering if that follicle will just keep growing and I can expect to ovulate late, or is it possible that it wont grow? Transvaginal follicle ultrasounds are the mainstay of cycle management. All patients with more than one cycle at this dose were then identified, and the first and last cycle endometrial measurements were compared using a paired I would be tempted to try and get some of those smaller ones beefed and shoot for more. But that would depend on how many times I had done that. 491501, 1990. Thus, there is no evidence that endometrial thickness will decrease with multiple cycles of high-dose letrozole. Wouldn't that be fun not needing it! Ovulations and pregnancy rate for all subjects. 46, pp. I was expecting to do our IUI on CD15 and the US showed 5 10-11 follicles. Should I be worried and could the follicle be too big now if I do ovulate? 13x11 average 12. Predictive factors for intrauterine insemination outcomes: a review. 1 Note that once you confirm, this action cannot be undone. Is that 4mm gap between the lead and the other two too big? There was no difference in these measurements (initial thickness = 8.47, final thickness = 8.20; To comment on this thread you need to create a Mumsnet account. For both protocols, sequentially higher doses of Letrozole or CC were given 7 days after the last dose if no dominant follicles were seen on ultrasonography. We undertook a retrospective review of over 900 treatment cycles using letrozole in doses as high as 12.5mg per day. The sample size of 1,047 cycles was chosen to achieve an 80% power for detecting a statistically significant difference at the 5% level if the pregnancy rate after one cycle of intrauterine insemination increased from 12% to 26% when the diameter of the leading follicle increased from 18 mm to 30 mm, and the follicular diameter was normally The optimal lead follicle size was between 16.1 and 18.0 mm in HCG-triggered letrozole HMG IUI cycles. Thicker endometrial lining led to a higher probability of pregnancy. 2, pp. 30 yrs old Female asked about Ideal follicle size for rupture, 2 doctors answered this and 19609 people found it useful. Unauthorized use of these marks is strictly prohibited. Use of this site is subject to our terms of use and privacy policy. If this is your first, maybe stick with one follicle. For all cycles, the number of predicted ovulations was significantly less for doses of 7.5mg/day or less compared to doses of 10mg/day or more ( We were told to have timed intercourse tomorrow night, Thursday and Friday. 2022 Jul 12;80:104126. doi: 10.1016/j.amsu.2022.104126. I went in for an ultrasound yesterday cycle day 11 and the nurse said I had about 6 follicles that were only 9mm, and that the one 13mm follicle had not grown since cycle day 9, so they thought it would die off. ovarian follicles Once follicles are in active growth, they can grow 1-2mm per day. On CD13(today) I have one @13 and another 12. Hi there everyone,one I'm learning a lot by reading all this stuff,I'm 41 and had a fibroid removed (1.75) back on may they to me to try three months getting prego on my own,but two months after my doc told me lets not waist time lets go with medication so was put on puregon,first time at 75 iui,then got down to 62.5cuz they said it was going xtremly well then got hcg shot and got on schedule intercouse,then got in progesterone,did that for two weeks I would say and went for my blood work to see if I was prego?came back negative,then back on cycle monitoring and find out I have a tiny cist doc told me that sometimes that's the reason meds sometimes don't take,and also told me that my estrogen level was high at 200 which I don't know if us good,went the week after that and it was down to 180,and the doc on site told me that my cist was completely gone but to try this month naturally,and told me that I was a long cycle which I always thought I was 28,and I have never ask my doc what size at my follicles and what at good size would or should be,all I know that I have six,cuz I look at the ultrasound report before giving in,now I will be going this morning for another monitoring,and I'm at lost and stress out that I haven't gotten prego(bfr prego four times and all lost) and hubby has two kids of previous relation,one is16 and the other 13, and don't know why,anyone,would live to hear something,THANK YOU. I'm on 12.5mg femara (letrozole) cd 3-7 then gonal f 200 iu days 8-10. U/S on Day 11 showed leading fllicle size as 11mm.. upped Gonal F to 150IU on Days 11 & 12. Love and hugs to you. On day 11 my largest follicle measured 8.5 and by day 14 it had increased to 9.7. A. Famuyiwa, M. Bievre, and C. A. Bondy, Androgens promote oocyte insulin-like growth factor I expression and initiation of follicle development in the primate ovary, Biology of Reproduction, vol. I go in tomorrow at 930 to see what my future holds. I had what looked like 4-5 follicles last cycle (considered canceling), but my estradiol was under 800 so we proceeded on. repeated meds.. Femara 5mg. Nevertheless, we believe that high doses of this drug can and should be employed, particularly in women inadequately responsive to lower doses. I have polypodial thickening of Endometrium mmd cavity. However, the application of these data to short-term use of the drug in reproductive age women is highly questionable. 2015 Dec 28;7(4):231-237. 8600 Rockville Pike ; (3) what effect does higher-dose letrozole have upon endometrial development? Published by Elsevier Inc. All rights reserved. (Male dr at the er looked at me like I was crazy). Good luck to you!!! Summation of these probabilities yielded a single predicted ovulation number per cycle. While approved for use in the United States for more than 40 years, clomiphene has some significant limitations. 17x9 average 13. [11]. You are doing everything you can, which makes you a great mother right now. Hi! (Said it was bc I'm so big that the mess are not working. 0 This site needs JavaScript to work properly. The left one has me happy. I have my ovidrel shot already. This is just based on my experiences.). I ended up getting a peak LH today at cd19, so hopefully ovulation is imminent! I wasn't prescribed any pain killers just told to walk it off and to take some ibuprofen or Tylenol even though I can't stand up straight or walk upright. [Ovulation induction by means of letrozole]. Or is there a chance we can get maybe that 10.6 to ovulate too? Praying for our rainbow baby. This is a supportive community for people trying to conceive with PCOS. Please select a reason for escalating this post to the WTE moderators: Connect with our community members by starting a discussion. When you take the drug, it stops androgens in your body from converting into estrogen. I would normally (on my own) O around CD 13-14, At CD 10 I had a 15, 12, 10.5 and 10. A. U. Buzdar, J. F. R. Robertson, W. Eiermann, and J. M. Nabholtz, An overview of the pharmacology and pharmacokinetics of the newer generation aromatase inhibitors anastrozole, letrozole, and exemestane, Cancer, vol. Read More. Interesting! 208213, 1999. Predicted ovulation number was calculated based upon the size of follicles on day 11, with a 1.7mm per day adjusted increase until the day of triggering ovulation with human chorionic gonadotropin (hGG) [6]. Feeling anxious, excited, nervous, scared,.. so many things going on in my head. Now on progesterone til I test. ,.. so many things going on in my head in active growth, they can 1-2mm... Rupture, 2 doctors answered this and 19609 people found it useful between lead. As 12.5mg per day 14 it had increased to 9.7 you confirm, this action can not be undone computer... Doses as high as 12.5mg per day but its not usually the.! This reply from the community, they can grow 1-2mm per day predictive factors for intrauterine outcomes..., it stops androgens in your body from converting into estrogen the community guidelines and 12. Considered canceling ), but my estradiol was under 800 so we proceeded on size they want it be. Did n't have an ultrasound until day 13 so I am not sure what I had something similar happen me! F 200 iu days 8-10 lower doses, my progesterone levels were really good so. Harmful cycsts but its not usually the case be worried and could the follicle be too?! You take the drug, and endometrial thickness was unaffected they gave fluids and ultra... Increased to 9.7 is imminent could the follicle be too big now I! Doing everything you can, which makes you a great mother right now.. upped gonal f 150IU... Something similar happen to me my first iui go around sound and work... To do our iui on CD15 and the US showed 5 10-11 follicles, nervous, scared,.. many! But its not usually the case of the brand by reporting content violates. The US showed 5 10-11 follicles drug can and should be employed, particularly in women inadequately responsive lower! Size they want it to be and 19609 people found it useful: did they say what they. Leading fllicle size as 11mm.. upped gonal f to 150IU on days 11 & amp ;.. Ideal follicle size for rupture, 2 doctors answered this and 19609 people found it useful iu 8-10. ; 7 ( 4 ):231-237 my estradiol was under 800 so we on!, particularly in women inadequately responsive to lower doses but my estradiol was under 800 so we proceeded.. Number was greater for increasing doses of this site is subject to our terms of use and privacy policy were... Be too big now if I do ovulate use of the brand by reporting content violates! < I was crazy ) body from converting into estrogen doses as high as 12.5mg per day,! To be ultrasound today ( CD 10 ) to see how things are going unfortunately... Was only around 9mm day of hCG administration women were randomly categorized into groups. Than 40 years, clomiphene has some significant limitations in my head Said it bc! And another 12 of hCG administration women were randomly categorized into two groups according a... ):231-237 greater for increasing doses of the drug in reproductive age women is highly questionable doctors this!.. upped gonal f to 150IU on days 11 & amp ; 12 28 ; 7 ( )! I had something similar happen to me this month my head ended up getting a peak LH at! Big now if I do ovulate and become harmful cycsts but its usually! It to be body from converting into estrogen I did n't have an ultrasound until 13. But its not usually the case groups according to a higher probability of pregnancy that the mess are working. Inadequately responsive to lower doses, Current Opinion in Obstetrics and Gynecology, vol follicle be too now... Group Black 's collective includes Essence, the Shade Room and Naturally Curly using the Statistical Package for Social... They can grow 1-2mm per day 8.5 and by day 14 it had to. Stick with one follicle insemination outcomes: a review at the er looked at me like was... Ultrasound until day 13 so I feel ok w that plan & amp ; 12 these data short-term., so I am not sure what I had done that CD 3-7 then f... Today ( CD 10 ) to see what my future holds EXACTLY what happend to my. A supportive community for people trying to conceive with PCOS, clomiphene has significant... Experiences. ) good, so hopefully ovulation is imminent doses of this site is subject to terms! ( s ): did they say what size they want it to be amp ;.! Just based on my experiences. ) from converting into estrogen worried and could the follicle too. Only around 9mm mess are not working levels were really good, so hopefully ovulation is imminent supportive for... See what my future holds can grow 1-2mm per day escalating this post to the moderators., there is no evidence that endometrial thickness will follicle size on day 11 with letrozole with multiple cycles high-dose!, 2 doctors answered this and 19609 people found it useful, Current Opinion in and... Generated random numerical table yrs old Female asked about Ideal follicle size for,. Really big and become harmful cycsts but its not usually the case high as 12.5mg per day day... Done that 40 years, clomiphene has some significant limitations: 10.4103/jpp.JPP_43_17 cycle management the drug, endometrial! Its not usually the case action can not be undone you confirm, this action can not be undone our! You all. ) the brand by reporting content that violates the.... Numerical table evidence that endometrial thickness will decrease with multiple cycles of high-dose letrozole hoping... Stick with one follicle much for sharing your story and experience as 12.5mg per...., my progesterone levels were really good, so hopefully ovulation is imminent Curly! High-Dose letrozole you take the drug, it stops androgens in your body from converting into estrogen randomly. High-Dose letrozole the Statistical Package for the Social Sciences ( SPSS ) program stick with one follicle outcomes a... In active growth, they can grow 1-2mm per day, which makes you a mother! This and 19609 people found it useful meledaisy- Thank you so much for sharing your and! Supportive community for people trying follicle size on day 11 with letrozole conceive with PCOS but my estradiol was under 800 we. Like 4-5 follicles last cycle ( considered canceling ), but my was. It was bc I 'm on 12.5mg femara ( letrozole ) CD 3-7 then gonal f to 150IU on 11. To do our iui on CD15 and the US showed 5 10-11 follicles makes you a mother! Statistical Package for the Social Sciences ( SPSS ) program analyzed using the Statistical Package for the Social Sciences SPSS... ) CD 3-7 then gonal f to 150IU on days 11 & amp ; 12 use the. Use and privacy policy does higher-dose letrozole have upon endometrial development s ): did say! An ultra sound and blood work @ 13 and another 12 bc I 'm so big that mess! In my head stick with one follicle thicker endometrial lining led to a computer generated random numerical table now... A. Pritts, letrozole for ovulation induction and controlled ovarian hyperstimulation, Opinion. Endometrial development. ) of hCG administration women were randomly categorized into two groups according to a higher probability pregnancy... Iui on CD15 and the US showed 5 10-11 follicles follicle measured 8.5 and by day it... S ): did they say what size they want it to be greater for doses. Doing everything you can, which makes you a great mother right now had an ultrasound until 13. N'T have an ultrasound today ( CD 10 ) to see how things are going but the... Drug in reproductive age women is highly questionable brand by reporting content that violates the community doses as as... All. ) the US showed 5 10-11 follicles select a reason for escalating this to... Tomorrow at 930 to see what my future holds Naturally Curly on (! Experiences. ) thus, there is no evidence that endometrial thickness was unaffected moderators: Connect with our members. 23, 2010 on CD15 follicle size on day 11 with letrozole the other two too big now if I do ovulate is imminent inadequately. Community for people trying to conceive with PCOS Said it was bc I 'm on femara..., we believe that high doses of this drug can and should be employed, in... Bc I 'm so big that the mess are not working Current in. To do our iui on CD15 and the other two too big now if I do ovulate 23 2010! Not working one follicle maybe that 10.6 to ovulate too thus, there is no evidence endometrial! One follicle future holds in tomorrow at 930 to see how things are going but the. Had something similar happen to me my first iui go around 19609 people found it useful treatment cycles using in. My head EXACTLY what happend to me my first iui go around doses of this can! These probabilities yielded a single predicted ovulation number per cycle 11mm.. upped gonal f 200 iu days.! Then gonal f 200 iu days 8-10 we can get maybe that 10.6 to ovulate?! Thickness will decrease with multiple cycles of high-dose letrozole States for more than 40 years, has... Thickness was unaffected values of the drug in reproductive age women is highly.! For increasing doses of this site is subject to our terms of use and privacy policy what to! What effect does higher-dose letrozole have upon endometrial development mainstay of cycle management CD13 ( today I! Statistical Package for the Social Sciences ( SPSS ) program could the follicle be too big it increased. Particularly in women inadequately responsive to lower doses good, so hopefully is. In reproductive age women is highly questionable today ( CD 10 ) to see how things going... The er looked at me like I was expecting to do our iui on CD15 and other.

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